A Statistical Atlas of Prostate Cancer for Optimal Biopsy
نویسندگان
چکیده
This paper presents a methodology of creating a statistical atlas of spatial distribution of prostate cancer from a large patient cohort, and uses it for designing optimal needle biopsy strategies. In order to remove inter-individual morphological variability and determine the true variability in cancer position, an adaptive-focus deformable model (AFDM) is used to register and normalize prostate samples. Moreover, a probabilistic method is developed for designing optimal biopsy strategies that determine the locations and the number of needles by optimizing cancer detection probability. Various experiments demonstrate the performance of AFDM in registering prostate samples for construction of the statistical atlas, and also validate the predictive power of our atlas-based optimal biopsy strategies in detecting prostate cancer.
منابع مشابه
Application of statistical cancer atlas for 3D biopsy
Prostate cancer is the most commonly diagnosed cancer in males in the United States and the second leading cause of cancer death. While the exact cause is still under investigation, researchers agree on certain risk factors like age, family history, dietary habits, lifestyle and race. It is also widely accepted that cancer distribution within the prostate is inhomogeneous, i.e. certain regions ...
متن کاملOptimized prostate biopsy via a statistical atlas of cancer spatial distribution
A methodology is presented for constructing a statistical atlas of spatial distribution of prostate cancer from a large patient cohort, and it is used for optimizing needle biopsy. An adaptive-focus deformable model is used for the spatial normalization and registration of 100 prostate histological samples, which were provided by the Center for Prostate Disease Research of the US Department of ...
متن کاملComparison of PSA profile with positive prostate cancer pathology and Gleason scores in 2015-2017 in Hamadan
Background and Objective: Prostate cancer is one of the most common cancers of the urinary system. The most used method for diagnosis is transrectal ultrasonography-guided biopsy. The purpose of this study is a statistical analysis with the aim of reducing unnecessary biopsies based on individual, geographical and genetic patterns in our region. Methods: The medical records of all patients who...
متن کاملWhat is the most appropriate test in detecting prostate cancer in patients with intermediate prostate specific antigen levels?
Abstract Background: Regarding the variety of tests present for detecting and also screening prostate cancer and also bearing in mind the advantages and disadvantages of these tests we decided to re-evaluate these tests (total prostate specific antigen and all of its modifications) in detecting prostate cancer in men with intermediate serum PSAlevels. Methods: Following a cross se...
متن کاملStatistical 3D prostate imaging atlas construction via anatomically constrained registration
Statistical imaging atlases allow for integration of information from multiple patient studies collected across different image scales and modalities, such as multi-parametric (MP) MRI and histology, providing population statistics regarding a specific pathology within a single canonical representation. Such atlases are particularly valuable in the identification and validation of meaningful im...
متن کامل